Super Eagles coach, Gernot Rohr has made three changes to the Super Eagles team that defeated Poland on Friday as Ahmed Musa starts against Serbia.
Tyronne Ebuehi, who was a second half substititute in the win against Poland, also wins a place in the starting lineup.
Odion Ighalo and Kelechi Iheanacho drop to the bench as Ahmed Musa and Onazi come into the squad.
Victor Moses, Iwobi and Joel Obi keep their place in the Nigerian starting 11 as the team looks to deploy the 4-3-3 formation.
Meanwhile, a late fitness issue has seen Leon Balogun replaced in the starting lineup by Chidozie Awaziem
The match is expected to kick-off at 8pm Nigerian time
Nigeria Starting XI: Francis Uzoho, Ebuehi, Troost-Ekong, Awaziem, Idowu, Ndidi, Joel Obi, Onazi, Iwobi, Moses, Musa